Abstract
Nowadays, biodegradable polymers are attractive candidates to create highperformance and environmentally friendly catalytic species. Polymeric materials for catalytic processes must be biocompatible and preferably biodegradable. Sulfonic acid functionalized chitosan (CS-SO3H) was easily prepared by the reaction of chitosan with chlorosulfonic acid. CS-SO3H is found to catalyze the Hantzsch reaction to produce 1,4-dihydropyridines (1,4DHPs) via the condensation reaction of aldehydes, ethyl acetoacetate and ammonium acetate with high efficiency. The use of heterogeneous and biodegradable CS-SO3H makes this synthetic methodology quite simple, more convenient and economically viable compared to homogeneous chitosan catalyzed method. CS-SO3H with nanopore structure, with encapsulated reactants may be applied as a nanoreactor for this chemical reaction. The main advantages of this protocol are the eco-friendly catalyst system, heterogeneous nature, freedom from organic solvents, and ease of the workup procedure. The present method can be used for the green design of heterocyclic compounds, and has potential for biological applications and drug discovery.
Keywords: Chitosan, chitosan-SO3H, heterogeneous catalysis, 1, 4-dihydropyridines, Hantzsch reaction.
Graphical Abstract
Related Books
2-Deoxy-D-Glucose: Chemistry and Biology
Chiral Ionic Liquids: Applications in Chemistry and Technology
Basics of Organic Chemistry: A Textbook for Undergraduate Students
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
51
2
1
1