Quinolones in the Search for New Anticancer Agents

Title:Quinolones in the Search for New Anticancer Agents

Volume: 22 Issue: 39

Author(s): Pedro Netto Batalha, Maria Cecília Bastos Vieira de Souza, Eduardo Peña-Cabrera, David Cruz Cruz and Fernanda da Costa Santos Boechat

Affiliation:

Keywords: Quinolones, cancer, topoisomerase, complexes, anticancer activity, photochemistry, natural products.

Abstract: Quinolones have a large bio-dynamicity. Although they are well known as antibacterials, another important activity has been investigated – quinolones are able to inhibit cancer cell proliferation. In view of the great versatility associated with the synthesis of quinolones, many researchers have spent time and resources on the development of new structurally diversified quinolone derivatives with the purpose of finding new possibilities for cancer treatment. In this review some of the most recent advances in the search for new quinolone anticancer agents are highlighted, with focus on naturally occurring substances, bioactive metal complexes, molecular hybrids, photosensitizers and heterocycle condensed quinolones.

Cite this article as:

Batalha Netto Pedro, Vieira de Souza Bastos Maria Cecília, Peña-Cabrera Eduardo, Cruz Cruz David and Santos Boechat Costa Fernanda da, Quinolones in the Search for New Anticancer Agents, Current Pharmaceutical Design 2016; 22 (39) . https://dx.doi.org/10.2174/1381612822666160715115025