巨噬细胞和肿瘤细胞蛋白质巯基亚硝基化的新作用

Title:Emerging Roles of Protein S-Nitrosylation in Macrophages and Cancer Cells

Volume: 23 Issue: 24

Author(s): Moran Benhar

Affiliation:

关键词: S -亚硝基化，巨噬细胞，肿瘤，炎症，硫氧还原蛋白，谷胱甘肽，蛋白质组学。

摘要: Despite long and intensive investigation, the mechanisms by which nitric oxide (NO) regulates immune function and carcinogenesis remain incompletely understood. Protein S-nitrosylation, the covalent attachment of a nitroso group to a cysteine thiol, has emerged as a central mechanism of NO-dependent cellular regulation. In particular, recent research has revealed important roles for S-nitrosylation/denitrosylation in modulating the activity of macrophage and tumor cell proteins, implicating Snitrosylation in the regulation of macrophage function as well as in tumor development and response to therapy. This review summarizes recent progress in the identification and characterization of S-nitrosylated proteins in macrophages and cancer cells. The review highlights key findings and insights obtained from functional and proteomic studies about the roles of S-nitrosylation in signaling, transcription, apoptosis and other cellular processes relevant to macrophage function and cancer progression. Some of the implications of recent discoveries for the development of novel anticancer approaches are also discussed.

Cite this article as:

Moran Benhar , Emerging Roles of Protein S-Nitrosylation in Macrophages and Cancer Cells, Current Medicinal Chemistry 2016; 23 (24) . https://dx.doi.org/10.2174/0929867323666160627114839