5-Alkylidenethiophen-2(5H)-ones as Biofilm Inhibitors

Tore      Benneche; Elahe   Jafari   Chamgordani; Gunnar      Herstad; Bjørg   Siw Møller   Tannæs; Anne   Aamdal   Scheie

doi:10.2174/1570178613666160620114658

Abstract

A number of thiophen-2(5H)-ones with different substituents in the 3-, 4- and 5-position have been synthesized and tested as inhibitors of biofilm production by the marine bacterium Vibrio harveyi BB120. Concentrations that inhibited 50% or 90% of biofilm formation (BIC₅₀, BIC₉₀) and of plantonic growth (PIC₅₀, PIC₉₀) are reported.

Keywords: 5-alkylidenethiophen-2(5H)-ones, biofilm inhibition, quorum sensing, synthesis.

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Letters in Organic Chemistry

Title:5-Alkylidenethiophen-2(5H)-ones as Biofilm Inhibitors

Volume: 13 Issue: 6

Author(s): Tore Benneche, Elahe Jafari Chamgordani, Gunnar Herstad, Bjørg Siw Møller Tannæs and Anne Aamdal Scheie

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Keywords: 5-alkylidenethiophen-2(5H)-ones, biofilm inhibition, quorum sensing, synthesis.

Abstract: A number of thiophen-2(5H)-ones with different substituents in the 3-, 4- and 5-position have been synthesized and tested as inhibitors of biofilm production by the marine bacterium Vibrio harveyi BB120. Concentrations that inhibited 50% or 90% of biofilm formation (BIC₅₀, BIC₉₀) and of plantonic growth (PIC₅₀, PIC₉₀) are reported.

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Benneche Tore, Chamgordani Jafari Elahe, Herstad Gunnar, Tannæs Siw Møller Bjørg and Scheie Aamdal Anne, 5-Alkylidenethiophen-2(5H)-ones as Biofilm Inhibitors, Letters in Organic Chemistry 2016; 13 (6) . https://dx.doi.org/10.2174/1570178613666160620114658

DOI https://dx.doi.org/10.2174/1570178613666160620114658	Print ISSN 1570-1786
Publisher Name Bentham Science Publisher	Online ISSN 1875-6255