Critical Review Upon the Role and Potential of Fluorescence and Near-Infrared Imaging and Absorption Spectroscopy in Cancer Related Cells, Serum, Saliva, Urine and Tissue Analysis

Christian W. Huck, Yukihiro Ozaki, Verena A. Huck-Pezzei

doi:10.2174/0929867323666160607110507

摘要

在过去的几年里，非侵入性或微创的诊断工具在癌症诊断中变得越来越重要。目前针对各种各样的癌症已经建立了多种荧光光谱方法学，原因是由于它灵敏度高、样品需求量低、测量时间短以及原位测试的适用性。本文描述了癌症诊断的潜在影响因素和随后针对不用应用所提出的适用性的方法。近红外光谱（NIRS）是基于癌症与正常组织之间内源性发色团的区别，通过利用氧合血红蛋白和脱氧血红蛋白、血脂或水带，或结合两种或两种以上的诊断标记物。这些标记带是已知的为几种癌症的诊断提供基础，并且光谱设置能被用于细胞、尿液和组织的分析。本文综述了过去十五年的研究，概述了荧光和近红外光谱分析工具在癌症分析中如癌症诊断、治疗决策和治疗中起着至关重要的作用性。

关键词: 荧光，近红外光谱，细胞，血清，尿液，唾液，组织

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Current Medicinal Chemistry

Title:Critical Review Upon the Role and Potential of Fluorescence and Near-Infrared Imaging and Absorption Spectroscopy in Cancer Related Cells, Serum, Saliva, Urine and Tissue Analysis

Volume: 23 Issue: 27

Author(s): Christian W. Huck, Yukihiro Ozaki, Verena A. Huck-Pezzei

Affiliation:

关键词: 荧光，近红外光谱，细胞，血清，尿液，唾液，组织

摘要: During the last years, non-invasive or minimally invasive diagnostic tools in cancer diagnostics have become more important. Many fluorescence spectroscopic methodologies have been established for nearly all different kinds of cancer. The reason therefore is its high sensitivity, low amount of sample required, short testing time, and the suitability for in situ testing. The potential influence factors for cancer diagnostics and the subsequent suitability of the method to different applications are well described.

Near-Infrared spectroscopy (NIRS) is based on differences of endogenous chromophores between cancer and normal tissues using either oxyhaemoglobin or deoxy-haemoglobin, lipid or water bands, or a combination of two or more of these diagnostic markers. These marker bands are known to provide the fundamental for the diagnosis of several cancers and the spectroscopic setup can be applied for the analysis of cells, urine and tissue. For the preparation of this review the literature published during the last fifteen years has been taken into consideration. It will provide an overview on the importance of the fluorescence and NIRS tools in cancer analysis giving hints about how these techniques can play a crucial role in cancer diagnosis, treatment decisions and therapy.

The two techniques, fluorescence and near-infrared spectroscopy (NIRS) are faced to each other and individual advantages and/or drawbacks are discussed. Finally, it will be taken into consideration; how the synergistic combination of different approaches can give additional information related to development and progression stages of cancer.

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Christian W. Huck, Yukihiro Ozaki, Verena A. Huck-Pezzei , Critical Review Upon the Role and Potential of Fluorescence and Near-Infrared Imaging and Absorption Spectroscopy in Cancer Related Cells, Serum, Saliva, Urine and Tissue Analysis, Current Medicinal Chemistry 2016; 23 (27) . https://dx.doi.org/10.2174/0929867323666160607110507

DOI https://dx.doi.org/10.2174/0929867323666160607110507	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X