A Systems Biology Perspective on Molecular Cytogenetics

Title:A Systems Biology Perspective on Molecular Cytogenetics

Volume: 12 Issue: 1

Author(s): Henry H.Q. Heng and Sarah Regan

Affiliation:

Keywords: Genome theory, system inheritance, fuzzy inheritance, somatic cell evolution, systems-integrated cytogenetics, non clonal chromosome aberration (NCCA)

Abstract: Background: With the rapid progress of various large scale sequencing and -omics technologies, molecular cytogenetics is entering a new era: Systems-integrated cytogenetics. Since the genome context rather than gene content defines the genome system by providing system inheritance, and genomic inheritance is less precise than we expected, the new cytogenetics will play an important role in advancing systems biology.

Objective: In this perspective, we briefly review some of the progress and limitations of the gene- or pathway- focused system approaches, including bioinformatics, and call for using the genome theory to integrate molecular cytogenetics and systems biology.

Method: By highlighting some recent developments from cytogenetics/cytogenomics and systems biology, we try to synthesize the new emergent field: systems-integrated cytogenetics.

Results: We explain why cytogenetics/cytogenomics needs a systems biology perspective, and what the major challenges and future directions are for the field of cytogenetics.

Conclusion: The future cytogenetics needs a new genome-based conceptual framework such as the genome theory. The integration of cytogenetics/cytogenomics with systems biology will mutually benefit both fields.

Cite this article as:

Heng H.Q. Henry and Regan Sarah, A Systems Biology Perspective on Molecular Cytogenetics, Current Bioinformatics 2017; 12 (1) . https://dx.doi.org/10.2174/1574893611666160606163419

DOI https://dx.doi.org/10.2174/1574893611666160606163419	Print ISSN 1574-8936
Publisher Name Bentham Science Publisher	Online ISSN 2212-392X