对类风湿性关节炎从关节腔内给药的药物

Title:Nanomedicine for Intra-Articular Drug Delivery in Rheumatoid Arthritis

Volume: 23 Issue: 23

Author(s): Hannah O'Mary, Inmaculada del Rincόn, Zhengrong Cui

Affiliation:

关键词: 抗关节炎药物；慢性炎症；通过渗漏血管外渗；发炎的关节；纳米粒子；单克隆抗体；siRNA。

摘要: Rheumatoid arthritis is characterized by chronic inflammation within the joint. Recent developments in the understanding of inflammation have led to an increased interest in the use of nanomedicine in the treatment and diagnosis of rheumatoid arthritis. The ability of nanomedicine, such as nanoparticles, to permeate into and/or retain within the inflamed joint after intravenous and/or intra-articular administration has proven to be beneficial in improving rheumatoid arthritis therapy while reducing systemic exposure of patients to potentially toxic anti-arthritic drugs. This review aims at explaining the major applications of nanomedicine in rheumatoid arthritis treatment and diagnosis.

Cite this article as:

Hannah O'Mary, Inmaculada del Rincόn, Zhengrong Cui , Nanomedicine for Intra-Articular Drug Delivery in Rheumatoid Arthritis, Current Medicinal Chemistry 2016; 23 (23) . https://dx.doi.org/10.2174/0929867323666160530144445