药物化学中使用模型和多种靶向药物进行设计

Title:The Use of Stilbene Scaffold in Medicinal Chemistry and Multi- Target Drug Design

Volume: 23 Issue: 23

Author(s): Elisa Giacomini, Sebastiano Rupiani, Laura Guidotti, Maurizio Recanatini, Marinella Roberti

Affiliation:

关键词: 烯烃的芳基化；阿尔茨海默病；癌症；考布他汀；己烯雌酚；双键的形成；混合化合物；白藜芦醇。

摘要: The stilbene scaffold is a basic element for a number of biologically active natural and synthetic compounds, and it is considered as a privileged structure. Stilbenes exemplified by resveratrol, combretastatin A-4 and pterostilbene are of significant interest for drug research and development because of their potential in therapeutic and preventive application. Resveratrol, present in grapes and other food products, plays a role in the prevention of several human pathological processes and has been suggested as an anticancer agent. Moreover, recent evidence has revealed its potential effect on the aging process, diabetes and neurological dysfunction. Combretastatin A-4, from the bark of South African bush willow Combretum caffrum, also shows significant antitumor activity. Pterostilbene is closely related to resveratrol, sharing the same unique therapeutic potential as anti-inflammatory, antineoplastic and antioxidant agent.

Therefore, research and development of stilbene-based medicinal chemistry have become rapidly evolving and increasingly active topics covering almost the whole range of therapeutic fields.

In the present review, we provide an overview of the role of stilbenes in medicinal chemistry. In this context, we highlight the chemical methodologies adopted for the synthesis of stilbene derivatives, and outline the successful design of novel stilbene based hybrids in the field of cancer, Alzheimer’s and other relevant diseases. This information may be useful in further design of stilbene-based molecules as new leads for the development of novel agents with clinical potential or as effective chemical probes to dissect biological processes.

Cite this article as:

Elisa Giacomini, Sebastiano Rupiani, Laura Guidotti, Maurizio Recanatini, Marinella Roberti , The Use of Stilbene Scaffold in Medicinal Chemistry and Multi- Target Drug Design, Current Medicinal Chemistry 2016; 23 (23) . https://dx.doi.org/10.2174/0929867323666160517121629