The Therapeutic Role of Taurine in Ischaemia-Reperfusion Injury

Title: The Therapeutic Role of Taurine in Ischaemia-Reperfusion Injury

Volume: 10 Issue: 19

Author(s): R. Kingston, C. J. Kelly and P. Murray

Affiliation:

Keywords: antioxidants, ischaemia-reperfusion injury, lipid peroxidation, oxidative stress, reperfusion, taurine

Abstract: As a non-toxic endogenous antioxidant, the semi-essential amino acid taurine is a potential attenuator of oxidative damage such as that produced by ischaemia-reperfusion injury. Ischaemia-reperfusion injury is a well established if paradoxical phenomenon whereby ischaemic tissue, doomed to necrosis if it is not reperfused, is actually further damaged by oxidative attack when perfusion is restored. This paper is a review of the literature concerning therapeutic strategies in ischaemia-reperfusion injury, including nonpharmacological and pharmacological interventions. There is consistent experimental evidence of an important role of taurine in ischaemia-reperfusion injury, with a clinical role emerging in human trials of taurine administered prior to coronary artery bypass grafting and heart valve surgery.

Cite this article as:

Kingston R., Kelly J. C. and Murray P., The Therapeutic Role of Taurine in Ischaemia-Reperfusion Injury, Current Pharmaceutical Design 2004; 10 (19) . https://dx.doi.org/10.2174/1381612043384015