Glycoconjugates of Quinolines: Application in Medicinal Chemistry

Title:Glycoconjugates of Quinolines: Application in Medicinal Chemistry

Volume: 16 Issue: 15

Author(s): Valentina Oliveri and Graziella Vecchio

Affiliation:

Keywords: Aggregation, bacteria, cancer, clioquinol, glycosides, infection, malaria, sugar.

Abstract: Compounds with the quinoline scaffold are widely investigated and offer a variety of therapeutical properties. A number of quinoline derivatives have been synthesized and among these there are glycoconjugated derivatives. Based on the interest for this family of compounds, we reviewed the different biological activities (molecular probes, antiinfective, antiproliferative, antiaggregant and antioxidant) and the potential applications in medicinal chemistry of quinoline glycoconjugates. This review wants to show an example of the glycoconjugation strategy which arose not only to modify the water solubility of the quinolines but also to influence their activity and targeting properties.

Cite this article as:

Oliveri Valentina and Vecchio Graziella, Glycoconjugates of Quinolines: Application in Medicinal Chemistry, Mini-Reviews in Medicinal Chemistry 2016; 16 (15) . https://dx.doi.org/10.2174/1389557516666160505115634