摘要
背景:沉默的两个或两个以上的互补信号通路可导致细胞死亡,而任何单一的基因功能的丧失并没有显示出严重的表型,这种相互作用称为“合成致死”。如今,合成性致死已成为广泛使用的抗癌策略。 方法:我们回顾了2016年以前抗肿瘤治疗中的合成致死相互作用。 结论:合成致死是行之有效的抗癌策略,更多的合成致命的相互作用已被转化成临床癌症的治疗。
关键词: 合成致死,靶向治疗,PARP抑制剂,耐药性,癌症治疗、信号转导通路。
图形摘要
Current Cancer Drug Targets
Title:Synthetic Lethal Interactions in Cancer Therapy
Volume: 17 Issue: 4
关键词: 合成致死,靶向治疗,PARP抑制剂,耐药性,癌症治疗、信号转导通路。
摘要: Background: Silencing of two or more complementary signaling pathways can lead to cell death, while loss of any single genetic function does not show a severe phnotype, this kind of inter action is coined as “synthetic lethality”. Nowadays, synthetic lethality has become a widely used anti-cancer strategy.
Method: We reviewed the synthetic lethal interactions exploited in anticancer therapies before 2016. Conclusion: Synthetic lethality is a well proved anticancer strategy and more synthetic lethal interactions is being translated into clinical cancer therapies.Export Options
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Cite this article as:
Synthetic Lethal Interactions in Cancer Therapy, Current Cancer Drug Targets 2017; 17 (4) . https://dx.doi.org/10.2174/1568009616666160426122736
DOI https://dx.doi.org/10.2174/1568009616666160426122736 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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