Abstract
The recognition of glycoprotein ligands by the selectins mediates leukocyte recruitment during an inflammatory response. Mimetics whose designs are based on the sialyl Lewis-x tetrasaccharide, common to these glycoproteins, have proven to be good inhibitors of leukocyte binding to the selectins. Some of the more recent approaches to the synthesis of these mimetics, including the use of polymeric and liposomal displays, multicomponent condensation reactions, and solid-phase peptide synthesis, are presented.
Keywords: Leukocyte Adhesion Inhibitors, solid-phase peptide, tetrasaccharide, polymeric
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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