植物雌激素木黄酮的ABC转运蛋白的表达和活性的调节：对药物配置的影响

Title:Modulation of Expression and Activity of ABC Transporters by the Phytoestrogen Genistein. Impact on Drug Disposition

Volume: 23 Issue: 13

Author(s): Juan Pablo Rigalli, Nadia Ciriaci, Aldo Domingo Mottino, Viviana Alicia Catania, María Laura Ruiz

Affiliation:

关键词: ATP结合盒转运体，乳腺癌耐药蛋白、染料木素、多药耐药相关蛋白，营养药物相互作用，P-糖蛋白，外源性运输。

摘要: ATP binding cassette (ABC) transporters are involved in drug absorption, distribution and elimination. They also mediate multidrug resistance in cancer cells. Isoflavones, such as genistein (GNT), belong to a class of naturally-occurring compounds found at high concentrations in commonly consumed soya based-foods and dietary supplements. GNT and its metabolites interact with ABC transporters as substrates, inhibitors and/or modulators of their expression. This review compiles information about regulation of ABC transporters by GNT with special emphasis on the three major groups of ABC transporters involved in excretion of endo- and xenobiotics as follows: Pglycoprotein (MDR1, ABCB1), a group of multidrug resistance associated proteins (MRPs, ABCC subfamily) and ABCG2 (BCRP), an ABC half-transporter. The impact of these regulations on potential GNT-drug interactions is further considered.

Cite this article as:

Juan Pablo Rigalli, Nadia Ciriaci, Aldo Domingo Mottino, Viviana Alicia Catania, María Laura Ruiz , Modulation of Expression and Activity of ABC Transporters by the Phytoestrogen Genistein. Impact on Drug Disposition, Current Medicinal Chemistry 2016; 23 (13) . https://dx.doi.org/10.2174/0929867323666160406120711