Abstract
Molecular genetic mechanisms show diversity during prostate carcinogenesis due to extensive tumor heterogeneity and gene complexity. Understanding the molecular mechanisms involved in initiation and progression of prostate cancer will lead to the development of strategies for early detection, prevention and therapeutic intervention. This review focuses on inheritable and sporadic prostate cancer genes involved in proliferation, metastasis, angiogenesis, tumor suppression, apoptosis, and cellular stress responses.
Keywords: prostate cancer, genetic abnormality, tumor suppressor genes, oncogenes, inheritable genes, metastasis, apoptosis, transcription factors
Current Genomics
Title: Genetic Abnormalities in Prostate Cancer
Volume: 5 Issue: 1
Author(s): Sanjeev Shukla, Gregory T. MacLennan, Susan R. Marengo, Allen D. Seftel, Martin I. Resnick and Sanjay Gupta
Affiliation:
Keywords: prostate cancer, genetic abnormality, tumor suppressor genes, oncogenes, inheritable genes, metastasis, apoptosis, transcription factors
Abstract: Molecular genetic mechanisms show diversity during prostate carcinogenesis due to extensive tumor heterogeneity and gene complexity. Understanding the molecular mechanisms involved in initiation and progression of prostate cancer will lead to the development of strategies for early detection, prevention and therapeutic intervention. This review focuses on inheritable and sporadic prostate cancer genes involved in proliferation, metastasis, angiogenesis, tumor suppression, apoptosis, and cellular stress responses.
Export Options
About this article
Cite this article as:
Shukla Sanjeev, MacLennan T. Gregory, Marengo R. Susan, Seftel D. Allen, Resnick I. Martin and Gupta Sanjay, Genetic Abnormalities in Prostate Cancer, Current Genomics 2004; 5 (1) . https://dx.doi.org/10.2174/1389202043490014
DOI https://dx.doi.org/10.2174/1389202043490014 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
New insights on Pediatric Tumors and Associated Cancer Predisposition Syndromes
Because of the broad spectrum of children cancer susceptibility, the diagnosis of cancer risk syndromes in children is rarely used in direct cancer treatment. The field of pediatric cancer genetics and genomics will only continue to expand as a result of increasing use of genetic testing tools. It's possible that ...read more
Related Journals

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Imaging Virus-Associated Cancer
Current Pharmaceutical Design Destination Penis? Gene Therapy as a Possible Treatment for Erectile Dysfunction
Current Gene Therapy Regulation of Hypoxia-inducible Factor-1α and Vascular Endothelial Growth Factor Signaling by Plant Flavonoids
Mini-Reviews in Medicinal Chemistry Prioritizing Disease Genes by Using Search Engine Algorithm
Current Bioinformatics Re-Wiring the Circuit: Mitochondria as a Pharmacological Target in Liver Disease
Current Medicinal Chemistry Adenovirus-based Immunotherapy for Prostate Cancer
Current Cancer Therapy Reviews Fertility Preservation in Women After the Cancer
Current Pharmaceutical Design Phytoestrogen Genistein and Its Pharmacological Interactions with Synthetic Endocrine-Active Compounds
Current Pharmaceutical Design Pancreatic Cancer and Personalized Medicine: Can Genomics Facilitate Early Diagnosis or Improve Therapeutic Outcomes?
Current Pharmacogenomics and Personalized Medicine Regulation of Radiation-Induced Apoptosis by Early Growth Response-1 Gene in Solid Tumors
Current Cancer Drug Targets Peptidic Tumor Targeting Agents: The Road from Phage Display Peptide Selections to Clinical Applications
Current Pharmaceutical Design The Role of Cytochrome P450 in Cytotoxic Bioactivation: Future Therapeutic Directions
Current Cancer Drug Targets Age-Dependent Changes of the temporal Order - Causes and Treatment
Current Aging Science Targeting the mTOR Pathway in Tumor Malignancy
Current Cancer Drug Targets A Brief Survey on Computational Approaches to Reveal Drug and Disease Associations
Current Drug Discovery Technologies Role of Iodine, Selenium and Other Micronutrients in Thyroid Function and Disorders
Endocrine, Metabolic & Immune Disorders - Drug Targets The Intriguing Interplay Between Therapies Targeting the Epidermal Growth Factor Receptor, the Hypoxic Microenvironment and Hypoxia-inducible Factors
Current Pharmaceutical Design Targeting CSCs in Tumor Microenvironment: The Potential Role of ROS-Associated miRNAs in Tumor Aggressiveness
Current Stem Cell Research & Therapy Current Progress of Reelin in Development, Inflammation and Tissue Remodeling: From Nervous to Visual Systems
Current Molecular Medicine Inhaled Biologics: From Preclinical to Product Approval
Current Pharmaceutical Design