Progress in Research of K_V1.1 and K_V1.3 Channels as Therapeutic Targets

Title:Progress in Research of K_V1.1 and K_V1.3 Channels as Therapeutic Targets

Volume: 16 Issue: 16

Author(s): Wei Zhao and Yuan Chen

Affiliation:

Keywords: Autoimmune disease, channel blocker, K_V1.1, K_V1.3, potassium channel, toxin.

Abstract: Voltage-gated potassium channels (K_V) mainly response in action potential repolarization in excitable cells and also participate in regulating resting potentials in non-excitable cells, involved in diverse physiological processes. This review focuses on potential drug developments targeting the K_V1.1 and K_V1.3 channels. K_V1.1 mainly existing in the nervous system plays key roles in controlling neuronal excitability; while the distribution of K_V1.3 in different types of cells contributes to a variety of cellular processes. This article seeks to review the distributions of two channels, their roles in diseases, phenotypes of knockout mice, human channelopathies and selective modulators.

Cite this article as:

Zhao Wei and Chen Yuan, Progress in Research of K_V1.1 and K_V1.3 Channels as Therapeutic Targets, Current Topics in Medicinal Chemistry 2016; 16 (16) . https://dx.doi.org/10.2174/1568026616666160315142920