Oxysterol / EBI2通路的作用在免疫系统和中枢神经系统

Title:The Role of the Oxysterol/EBI2 Pathway in the Immune and Central Nervous Systems

Volume: 17 Issue: 16

Author(s): Aleksandra Rutkowska, Kumlesh K. Dev, Andreas W. Sailer

Affiliation:

关键词: 星形胶质细胞.自身免疫. 中枢神经系统. EBI2.免疫系统. 神经退化. 少突胶质细胞

摘要: Oxysterols are pleiotropic messengers interacting with multiple receptor systems. One of the cognate receptors for oxysterols is EBI2, a G protein-coupled receptor highly expressed in the cells of the immune system. Here we discuss the receptor’s role in the adapted immunity and inflammation as well as the receptor’s expression and function in the CNS with the focus on astrocytes. We also discuss expression and signalling of oxysterol-producing enzymes such as CH25H and CYP7B1 in the CNS and the immune system. These steps will help to elucidate a possible role for this pathway in the physiology of the central and peripheral nervous system and its possible link to human disease.

Cite this article as:

Aleksandra Rutkowska, Kumlesh K. Dev, Andreas W. Sailer , The Role of the Oxysterol/EBI2 Pathway in the Immune and Central Nervous Systems, Current Drug Targets 2016; 17 (16) . https://dx.doi.org/10.2174/1389450117666160217123042