Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy?

Title:Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy?

Volume: 16 Issue: 27

Author(s): Elina Buitrago, Renaud Hardré, Romain Haudecoeur, Hélène Jamet, Catherine Belle, Ahcène Boumendjel, Luigi Bubacco and Marius Réglier

Affiliation:

Keywords: Melanoma, Tyrosinase, TRP-1, TRP-2, Tyrosinase effectors.

Abstract: Among the human copper-containing monooxygenases, Tyrosinase (Ty) is an important enzyme involved in the determinant step of the biosynthetic pathway of melanin pigment. In this pathway, Ty catalyzes the tyrosine monooxygenation into L-DOPA-quinone, which is the precursor of the skin pigment melanin. Ty inhibitors/activators are a well-established approach for controlling in vivo melanin production, so their development has a huge economical and industrial impact. Moreover, recent publications highlight that targeting tyrosinase with inhibitors/activators to treat melanogenesis disorders is one of many possible approaches, due to the complex biochemical reaction involved in the melanin synthesis.

Cite this article as:

Buitrago Elina, Hardré Renaud, Haudecoeur Romain, Jamet Hélène, Belle Catherine, Boumendjel Ahcène, Bubacco Luigi and Réglier Marius, Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy?, Current Topics in Medicinal Chemistry 2016; 16 (27) . https://dx.doi.org/10.2174/1568026616666160216160112