Acidity-Activated Shielding Strategies of Cationic Gene Delivery for Cancer Therapy

Title:Acidity-Activated Shielding Strategies of Cationic Gene Delivery for Cancer Therapy

Volume: 17 Issue: 3

Author(s): Jialiang Xia, Zongcai Feng, Hongyan Yang, Sanqing Lin and Bing Han

Affiliation:

Keywords: Cancer therapy, gene delivery, acidity responsive, shielding strategy.

Abstract: Cationic gene vectors increased attractive for gene therapy. However, unstable systemic circulation due to the interaction of gene delivery system with blood cells limited the further application. Therefore, pH sensitive shielding systems were exploited, by which, the positive surface charge density of polyplexes was reduced, circulation time was improved and pH-triggered targeting delivery was promised. This mini review mainly focuses on the development of solid tumors pH environment activated shielding systems for cationic gene vectors. This shielding strategy shows great potential for enhancing efficient gene transporting and achieving better therapeutic effects in acidic tumor treatment.

Cite this article as:

Xia Jialiang, Feng Zongcai, Yang Hongyan, Lin Sanqing and Han Bing, Acidity-Activated Shielding Strategies of Cationic Gene Delivery for Cancer Therapy, Current Pharmaceutical Biotechnology 2016; 17 (3) . https://dx.doi.org/10.2174/138920101703160206144220