An Efficient Four-Step Approach Toward Fused Triazino[1,6-a] Quinazolines

Title:An Efficient Four-Step Approach Toward Fused Triazino[1,6-a] Quinazolines

Volume: 19 Issue: 3

Author(s): Mohammad Hosein Sayahi, Shirin Baghersaei, Fereshteh Goli, Setareh Moghimi, Mohammad Mahdavi, Loghman Firoozpour, Abbas Shafiee and Alireza Foroumadi

Affiliation:

Keywords: N-N bond forming, Heterocyclization, Triazine, Quinazoline, Diazonium, Isatoic anhydride.

Abstract: Herein, we describe a simple, four-step process for the preparation of 1,2,3-triazino[1,6- a]quinazolin-13-ones. This method involves ring-opening, quinazoline-forming condensation, reduction, diazotization accompanied by rapid intramolecular cyclization in the last step afforded the desired products with structurally complex heterocyclic core in excellent to high yields.

Cite this article as:

Sayahi Hosein Mohammad, Baghersaei Shirin, Goli Fereshteh, Moghimi Setareh, Mahdavi Mohammad, Firoozpour Loghman, Shafiee Abbas and Foroumadi Alireza, An Efficient Four-Step Approach Toward Fused Triazino[1,6-a] Quinazolines, Combinatorial Chemistry & High Throughput Screening 2016; 19 (3) . https://dx.doi.org/10.2174/1386207319666160202120802