The Current Use of Mass Spectrometry in Combination with Other Separation Techniques in Drug Discovery Arena

Title:The Current Use of Mass Spectrometry in Combination with Other Separation Techniques in Drug Discovery Arena

Volume: 12 Issue: 5

Author(s): Piotr Kawczak and Tomasz Baczek

Affiliation:

Keywords: Mass spectrometry, LC-MS, drug discovery, drug development, ADMET.

Abstract: Mass spectrometry (LC-MS or LC-MS/MS) appears in all phases of drug discovery and drug development areas. Starting with the screening and identification of a therapeutic agent and further measuring its in vivo and in vitro properties include: absorption, distribution, metabolism, excretion and toxicity (ADMET) and also pharmacokinetic (PK) and pharmacodynamic (PD) quantitative parameters of drug candidate. Mass spectrometry also serves as a necessary tool also to confirm purity and stability of analyzed new chemical entities (NCEs)/new molecular entities (NMEs) as well as for the analysis of degradation products from the synthesis and following on every stages of drug discovery.

Cite this article as:

Kawczak Piotr and Baczek Tomasz, The Current Use of Mass Spectrometry in Combination with Other Separation Techniques in Drug Discovery Arena, Medicinal Chemistry 2016; 12 (5) . https://dx.doi.org/10.2174/1573406412666160106154856