心力衰竭中的炎症：新的保护性脂质介质

Title:Resolving Inflammation in Heart Failure: Novel Protective Lipid Mediators

Volume: 17 Issue: 10

Author(s): Marta Reina-Couto, Luís Vale, Jorge Carvalho, Paulo Bettencourt, António Albino-Teixeira, Teresa Sousa

Affiliation:

关键词: 心脏衰竭；炎症消退；proresolving脂类介质；心血管/代谢和肾脏保护；治疗方案。

摘要: Inflammation is an important pathogenic mechanism in chronic heart failure (HF). The perpetuation of the inflammatory response in this syndrome may result either from excessive activation of proinflammatory cascades or disturbances in the resolution of inflammation. However, although cardiovascular research has extensively investigated the proinflammatory processes involved in chronic HF pathophysiology, the mechanisms responsible for inflammation resolution in this disease remain largely disregarded. The resolving response is currently considered an active process involving specific effectors that limit the progression of inflammation and promote tissue regeneration. This article aims at reviewing the major classes of lipid mediators of inflammation resolution, their cardiovascular, metabolic and renal protective effects that might putatively delay the onset and progression of chronic HF, and their therapeutic modulation. Furthermore, it also aims to emphasize the importance of adopting therapeutic strategies that stimulate the resolution of inflammation in chronic HF.

Cite this article as:

Marta Reina-Couto, Luís Vale, Jorge Carvalho, Paulo Bettencourt, António Albino-Teixeira, Teresa Sousa , Resolving Inflammation in Heart Failure: Novel Protective Lipid Mediators, Current Drug Targets 2016; 17 (10) . https://dx.doi.org/10.2174/1389450117666160101121135