Abstract
Epothilones exhibit high antitumor activities with the same mechanism of action as Taxol and retain a much greater toxicity against p-glycoprotein overexpressing multiple drug resistant (MDR) cells. The realization of their unique potential as antitumor agents resulted in an intense race for their total synthesis, structure modification, and biological investigation. Recently a wealth of new chemistry has been developed in the synthesis of epothilone family. This review will present recent progress in the syntheses of epothilones and analogues.
Keywords: Epothilones, p-glycoprotein, Taxol
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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