心脏中的钙网蛋白：从胚胎学的发展到心脏病理学

Title:Calreticulin in the Heart: From Embryological Development to Cardiac Pathology.

Volume: 16 Issue: 1

Author(s): D. Martinho-Dias, A. Leite-Moreira and P. Castro-Chaves

Affiliation:

关键词: 钙网蛋白、内质网、胎儿致死、肥大、缺血-再灌注、扩张型心肌病、心律失常、心脏传导阻滞。

摘要: Background: Calreticulin is a Ca²⁺-binding chaperone in the endoplasmic reticulum (ER) which is crucial to the correct embryological development of the heart in mice. Altered expression levels in the adult were correlated with several cardiac pathologies such as cardiac hypertrophy and dilated cardiomyopathy.

Aim: In this review, we aim to describe the role of calreticulin in the embryological development of the heart in mice and to clarify the relationship between the different cardiac pathologies and altered expression levels of calreticulin in the adult heart.

Conclusion: There is an ER crucial to embryogenesis in cardiomyocytes besides SR. Certain stimuli may induce reactivation of the transcription pattern present during embryogenesis, leading to overexpression of calreticulin in the heart, altering numerous signaling pathways and subsequently inducing pathology. Normalization of these transcriptional disorders holds promise in the treatment of multiple cardiac diseases.

Cite this article as:

D. Martinho-Dias, A. Leite-Moreira and P. Castro-Chaves , Calreticulin in the Heart: From Embryological Development to Cardiac Pathology., Current Molecular Medicine 2016; 16 (1) . https://dx.doi.org/10.2174/1566524016666151222142816