Photoreorganization of 2-methyl-3-(prop-2-ynyloxy)-4H-chromen-4-ones: Synthesis of 4-methylcoumarin Derivatives

Title:Photoreorganization of 2-methyl-3-(prop-2-ynyloxy)-4H-chromen-4-ones: Synthesis of 4-methylcoumarin Derivatives

Volume: 13 Issue: 5

Author(s): Radhika Khanna, Aarti Dalal, Sanjeev Kumar, Ramesh Kumar and Ramesh C. Kamboj

Affiliation:

Keywords: Chromenones, coumarins, photo-irradiation, Norrish type-1 reaction, ring-opening /cyclization, γ-H abstraction.

Abstract: The coumarin derivatives have the anabolic, antioxidant, hepatoprotective, anticoagulant, HIV-proteases’ inhibitory, CNS depressant, hypnotics, sedative, diuretic, analgesic and antitubercular activities. In the present study, the synthesis of some 4-methylcoumarin derivatives in appreciably good yields has been achieved by the photo-irradiation of th e 2-methyl-3-(prop-2-ynyloxy)-4H-chromen-4-ones with pyrex filtered UV-light from 125W Hg lamp. The reaction is unprecedented and proceeded under mild and eco-friendly conditions within 60 minutes and may become an important tool for obtaining the 4-methylcoumarin derivatives.

Cite this article as:

Khanna Radhika, Dalal Aarti, Kumar Sanjeev, Kumar Ramesh and Kamboj C. Ramesh, Photoreorganization of 2-methyl-3-(prop-2-ynyloxy)-4H-chromen-4-ones: Synthesis of 4-methylcoumarin Derivatives, Current Organic Synthesis 2016; 13 (5) . https://dx.doi.org/10.2174/1570179413666151218202630