新兴的关于转移型肾细胞癌的免疫目标

Title:Emerging Immunotargets in Metastatic Renal Cell Carcinoma

Volume: 17 Issue: 7

Author(s): John Kucharczyk, Marc R. Matrana, Matteo Santoni, Francesco Massari, Marina Scarpelli, Liang Cheng, Antonio Lopez-Beltran and Stefano Cascinu, Rodolfo Montironi, Moch Holger

Affiliation:

关键词: 免疫治疗；免疫目标；转移性肾细胞癌；肾细胞癌。

摘要: Renal cell carcinoma (RCC) is one of the most immunoresponsive human cancers. High-dose IL-2 and Interferon-α were once the principle therapies for metastatic RCC, however they had harsh-tolerance profiles and limited response rates. In the last decade, targeted therapies have supplanted cytokine therapy due to higher response rates and more favorable toxicity profiles. Emerging immunotherapies targeting the PD-1 receptor and PD-L1 ligand have shown promising results. Likewise, other novel targeted immunotherapies are currently under evaluation. The safety profiles and response rates of new generation immunotherapies are encouraging and justify the progression of clinical trials. However, longer follow-up data are needed to confirm these promising results. In addition, it is still unclear if an optimal sequence or combinations of new immunotherapies paired with current targeted therapies will emerge.

Cite this article as:

John Kucharczyk, Marc R. Matrana, Matteo Santoni, Francesco Massari, Marina Scarpelli, Liang Cheng, Antonio Lopez-Beltran and Stefano Cascinu, Rodolfo Montironi, Moch Holger , Emerging Immunotargets in Metastatic Renal Cell Carcinoma, Current Drug Targets 2016; 17 (7) . https://dx.doi.org/10.2174/1389450117666151209115753