海洋海绵中天然产物的神经保护作用

Title:Neuroprotective Activities of Marine Natural Products from Marine Sponges

Volume: 23 Issue: 4

Author(s): Mousa Alghazwi, Yen Qi Kan and Wei Zhang

Affiliation:

关键词: 乙酰胆碱酯酶，阿尔茨海默病，淀粉样β，海绵，天然产物，神经生长因子，神经退行性疾病的神经保护作用，氧化应激，tau蛋白

摘要: This review covers the compounds isolated from marine sponges with neuroprotective activities during the period between 1999 and 2014 based on their chemical structures, collections sites, sponge taxonomy and neuroprotective effects. These compounds were isolated from marine sponges collected from 18 countries, most of them in Indonesia, followed by Japan. A total of 90 compounds were reported to exhibit a range of neuroprotective efficacy. These compounds were shown to inhibit β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1), modulate the synthesis or activity of some neurotransmitters such as acetylcholinesterase and glutamate, enhancement of serotonin, reducing oxidative stress, inhibition of kinases and proteases, and enhancement of neurite growth. None of them have yet progressed into any marine pharmaceutical development pipeline, therefore sustained researches will be required to enhance the potential of utilizing these compounds in the future for prevention and therapeutic treatment of neurodegenerative diseases.

Cite this article as:

Mousa Alghazwi, Yen Qi Kan and Wei Zhang , Neuroprotective Activities of Marine Natural Products from Marine Sponges, Current Medicinal Chemistry 2016; 23 (4) . https://dx.doi.org/10.2174/0929867323666151127201249