Design, Synthesis, and Fungicidal Activities of Novel 5-Methyl-1H-1,2,3- trizole-4-carboxyl Amide Analogues

Title:Design, Synthesis, and Fungicidal Activities of Novel 5-Methyl-1H-1,2,3- trizole-4-carboxyl Amide Analogues

Volume: 12 Issue: 3

Author(s): Zhen-Jun Wang, Hui-Hui Yang, Lei Tian and Wei-Guang Zhao

Affiliation:

Keywords: Succinate dehydrogenase inhibitors, 1, 2, 3-Triazole, fungicide, fungicidal activity relationship, synthesis.

Abstract: Succinate dehydrogenase inhibitors (SDHIs) are fungicides with an amide bond widely used to control plant diseases caused by phytopathogenic fungi. Because of broad spectrum activity of new SDHIs, they have attracted wide attention from the research community. A series of structurally novel SDHIs with a bioactive 1,2,3-triazole moiety were designed and synthesized. Bioactivity screening showed that some of designed N-phenethyl-1,2,3-trizole-4-carboxyl amide analogues exhibited good fungicidal activities toward Sclerotinia sclerotiorum and Botrytis cinerea, while some of Nbenzyl- 1,2,3-trizole-4-carboxyl amide analogues exhibited good fungicidal activities toward Phytophthora capsici and Cercospora arachidicola. EC₅₀ value of compound 5d against Cercospora arachidicola (6.6 µg/mL) was lower than that of chlorothalonil (12.3 µg/mL).

Cite this article as:

Wang Zhen-Jun, Yang Hui-Hui, Tian Lei and Zhao Wei-Guang, Design, Synthesis, and Fungicidal Activities of Novel 5-Methyl-1H-1,2,3- trizole-4-carboxyl Amide Analogues, Medicinal Chemistry 2016; 12 (3) . https://dx.doi.org/10.2174/1573406412666151112125006