Synthesis and Antimicrobial Activity of Mono, Bis and Tris 2-Amino-4HChromenes

Title:Synthesis and Antimicrobial Activity of Mono, Bis and Tris 2-Amino-4HChromenes

Volume: 12 Issue: 10

Author(s): Mohammad Nikpassand, Leila Zare Fekri, Hanieh Badri and Leila Asadpour

Affiliation:

Keywords: Antimicrobial, chromenes, ionic liquid, multicomponent reaction, α-Naphthol, malononitrile.

Abstract: A clean and environmentally benign route to 2-amino-4H-chromenes has been developed using the reaction between various benzaldehydes, malononitrile and α-naphthol in the presence of 3,3'-(pentane-1,5-diyl)bis(1,2-dimethyl-1H-imidazol-3-ium) bromide. The present methodology offers several advantages such as solvent-free conditions, excellent yields, simple procedure, mild conditions and reduced environmental consequences. The ionic liquid was recovered and reused. All of synthesized compounds were characterized by IR, NMR and Elemental analyses.

Cite this article as:

Nikpassand Mohammad, Fekri Zare Leila, Badri Hanieh and Asadpour Leila, Synthesis and Antimicrobial Activity of Mono, Bis and Tris 2-Amino-4HChromenes, Letters in Organic Chemistry 2015; 12 (10) . https://dx.doi.org/10.2174/157017861210151102151656