Advances in Peptide-based DNA/RNA-Intercalators

Title:Advances in Peptide-based DNA/RNA-Intercalators

Volume: 17 Issue: 2

Author(s): Josipa Matić, Lidija-Marija Tumir, Marijana Radić Stojković and Ivo Piantanida

Affiliation:

Keywords: DNA, RNA, peptide, intercalator, fluorescence, DNA-cleavage.

Abstract: Interactions between DNA/RNA and huge variety of peptides are quite common in nature, controlling vast number of processes. Also, there are several naturally occurring small molecules which contain peptide and DNA intercalator in structure, whereby their biological activity is based on synergistic interactions of both components; for instance bis-intercalator echinomycin. Versatility of synthetic approaches to short peptides allowed their usage as simple recognition units within the DNA or RNA grooves or as backbone carriers for variety of bioactive substituents attached to amino acid side chains, one of very popular examples being PNAs. Such peptide-backbones were also used for synthesis of novel intercalators and poly-intercalators, many of them showing intriguing novel DNA/RNA interacting properties.

Cite this article as:

Matić Josipa, Tumir Lidija-Marija, Stojković Radić Marijana and Piantanida Ivo, Advances in Peptide-based DNA/RNA-Intercalators, Current Protein & Peptide Science 2016; 17 (2) . https://dx.doi.org/10.2174/138920371702160209124439