在老化过程中AMPK的功能

Title:AMPK Function in Aging Process

Volume: 17 Issue: 8

Author(s): Rocío Ruiz, Eva María Pérez-Villegas, Ángel Manuel Carrión

Affiliation:

关键词: AMPK、衰老、代谢紊乱、氧化应激、衰老。

摘要: Aging involves the progressive deterioration of physiological functions, diminishing the individual’s capacity for survival. Indeed, aging is the main risk factor for cancer, diabetes, cardiovascular disorders and neurodegenerative diseases. The discovery that the rate of aging is controlled by conserved genetic and biochemical pathways represented an unprecedented advance in aging research. The AMPK protein is a metabolic sensor that acts as a qualified cellular housekeeper, as well as controlling energy homeostasis and resistance to stress. Thus, the correct regulation of this factor enhances health and survival. In this manuscript we will review the molecular pathways regulated by AMPK that are related to the aging process, paying special attention to mitochondrial dysfunction, metabolic deregulation, cell senescence and autophagy.

Cite this article as:

Rocío Ruiz, Eva María Pérez-Villegas, Ángel Manuel Carrión , AMPK Function in Aging Process, Current Drug Targets 2016; 17 (8) . https://dx.doi.org/10.2174/1389450116666151102095825