The Correlated Factors of Serum CA19-9 Levels in Diabetic Patients

Title:The Correlated Factors of Serum CA19-9 Levels in Diabetic Patients

Volume: 13 Issue: 1

Author(s): Qiuming Jiang, Lei Lei, Xiyang Zhang, Jennifer Pressley and Yuanjie Mao

Affiliation:

Keywords: CA19-9, diabetes mellitus, Hemoglobin A1c, C-peptide, total cholesterol, high-density lipoprotein cholesterol.

Abstract: Background: Serum CA19-9 level is a sensitive marker for pancreatic tissue damage; however, its correlation factors are still unclear in diabetic patients. This study was aimed to investigate the correlation factors of serum CA 19-9 levels in these patients.

Methods and Results: Based on their serum CA19-9 levels, 412 diabetic patients (57 type 1 and 355 type 2) were divided into the negative group (432 cases, CA19-9 < 37 U /ml) and the positive group (31 cases, CA19-9 ≥ 37 U /ml). The two groups were compared with age, sex, duration of diabetic history, hemoglobin A1c, blood lipid, fasting C-peptide level, and area under the curve C-peptide. The difference was significant between 2 groups in age, hemoglobin A1c, total cholesterol, highdensity lipoprotein cholesterol, fasting C-peptide level, and area under the curve C-peptide (P < 0.05). A multivariate linear regression model found that the type of diabetes, hemoglobin A1c, area under the curve C-peptide, and high-density lipoprotein cholesterol are the independent contributors to CA19-9 levels.

Conclusion: The results indicated that CA19-9 levels in patients with diabetes mellitus were related to not only age and sex but also diabetic type, hemoglobin A1c, lipid metabolism, and pancreatic beta cell function.

Cite this article as:

Jiang Qiuming, Lei Lei, Zhang Xiyang, Pressley Jennifer and Mao Yuanjie, The Correlated Factors of Serum CA19-9 Levels in Diabetic Patients, Current Diabetes Reviews 2017; 13 (1) . https://dx.doi.org/10.2174/1573399812666151012115546