Abstract
Introduction: Chalcones are one of the major classes of naturally occurring compounds and have a vast significance in medicinal chemistry, presenting with a wide scope of pharmacological actions.
Discussion: The present review focused our attention onto the monoamine oxidase inhibitory activity of natural and synthetic chalcones. The review also emphasises the structure-activity relationship studies and molecular recognition of chalcones towards MAO-A and B inhibition.
Conclusion: Many of the studies clearly revealed that most of the chalcones showed selective, reversible and potent MAO-B inhibition compared to MAO-A. Recent studies also showed that heteroaryl-based chalcones are potent MAO-A inhibitors.
Keywords: Alzheimer's disease, Chalcones, Depression, MAO-A, MAO-B.
Graphical Abstract
Central Nervous System Agents in Medicinal Chemistry
Title:Monoamine Oxidase Inhibitory Action of Chalcones: A Mini Review
Volume: 16 Issue: 2
Author(s): Bijo Mathew, Abitha Haridas, Jerad Suresh, Githa E. Mathew, Gülberk Uçar and Venkatesan Jayaprakash
Affiliation:
Keywords: Alzheimer's disease, Chalcones, Depression, MAO-A, MAO-B.
Abstract: Introduction: Chalcones are one of the major classes of naturally occurring compounds and have a vast significance in medicinal chemistry, presenting with a wide scope of pharmacological actions.
Discussion: The present review focused our attention onto the monoamine oxidase inhibitory activity of natural and synthetic chalcones. The review also emphasises the structure-activity relationship studies and molecular recognition of chalcones towards MAO-A and B inhibition.
Conclusion: Many of the studies clearly revealed that most of the chalcones showed selective, reversible and potent MAO-B inhibition compared to MAO-A. Recent studies also showed that heteroaryl-based chalcones are potent MAO-A inhibitors.
Export Options
About this article
Cite this article as:
Mathew Bijo, Haridas Abitha, Suresh Jerad, E. Mathew Githa, Uçar Gülberk and Jayaprakash Venkatesan, Monoamine Oxidase Inhibitory Action of Chalcones: A Mini Review, Central Nervous System Agents in Medicinal Chemistry 2016; 16 (2) . https://dx.doi.org/10.2174/1871524915666151002124443
DOI https://dx.doi.org/10.2174/1871524915666151002124443 |
Print ISSN 1871-5249 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6166 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
ADME Optimization and Toxicity Assessment in Early- and Late-Phase Drug Discovery
Current Topics in Medicinal Chemistry Vascular effects of flavonoids
Current Medicinal Chemistry Acid-Induced Unfolding of Champedak Galactose-Binding Lectin
Protein & Peptide Letters Analysis of Capsaicinoids in Hot Sauces Using a Silica Hydride-Based Stationary Phase
Current Chromatography Nimodipine Reappraised: An Old Drug With a Future
Current Neuropharmacology Multifaceted Synthesis, Properties and Applications of Polyurethanes and its Composites
Current Organic Chemistry Liver-Based In Vitro Technologies for Drug Biotransformation Studies - A Review
Current Drug Metabolism Viruses in Semen and Male Genital Tissues - Consequences for the Reproductive System and Therapeutic Perspectives
Current Pharmaceutical Design Predictive QSAR Modeling Workflow, Model Applicability Domains, and Virtual Screening
Current Pharmaceutical Design QSAR of Chalcones Utilizing Theoretical Molecular Descriptors
Current Computer-Aided Drug Design Biology and Impact of Signal Transducers and Activators of Transcription and Their Regulators as Targets in Cancer Therapy
Current Signal Transduction Therapy Therapeutic Potential of Photochemically Active Metal Complexes based on Interaction with Enzymes
Current Topics in Medicinal Chemistry Tea Consumption and Risk of Ischemic Stroke: a Brief Review of the Literature
Current Pharmaceutical Biotechnology Compounds Derived from Epigallocatechin-3-Gallate (EGCG) as a Novel Approach to the Prevention of Viral Infections
Inflammation & Allergy - Drug Targets (Discontinued) Discover Patent Landscape of Two-photon Polymerization Technology for the Production of 3D Nano-structure Using Claim-based Approach
Recent Patents on Nanotechnology Synthesis and Urease Inhibitory Activity of Some 5-Aminomethylene Barbituric/Thiobarbituric Acid Derivatives
Letters in Drug Design & Discovery Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library
Combinatorial Chemistry & High Throughput Screening Healthcare Management During A Pandemic: The Other Side of the Coin for the Treatment of COVID-19 Infection
Endocrine, Metabolic & Immune Disorders - Drug Targets Advances of Phenoxazines: Synthesis, Reactivity and Their Medicinal Applications
Current Medicinal Chemistry Using Genomics for Natural Product Structure Elucidation
Current Topics in Medicinal Chemistry