Calcium Handling and Arrhythmogenesis

Title:Calcium Handling and Arrhythmogenesis

Volume: 12 Issue: 2

Author(s): Georgios C. Bompotis, Loukas K. Pappas, Christos Angelidis, Charalampos Kossyvakis, Georgios Giannopoulos and Spyridon Deftereos

Affiliation:

Keywords: Calcium, arrhythmia, pathophysiology, pathogenesis.

Abstract: Intracellular calcium homeostasis plays a fundamental role in the electric and mechanical function of the heart by modulating action potential pattern and duration, by linking cell membrane depolarization to myocardial contraction and by regulating cardiac automaticity. Abnormalities of intracellular calcium regulation disrupt the electrophysiological properties of the heart and create an arrhythmogenic milieu, which promotes atrial and ventricular arrhythmogenesis and impairs cardiac automaticity and atrioventricular conduction. In this brief review, we summarize the basic genetic, molecular and electrophysiological mechanisms linking inherited or acquired intracellular Ca²⁺ dysregulation to arrhythmogenesis.

Cite this article as:

Bompotis C. Georgios, Pappas K. Loukas, Angelidis Christos, Kossyvakis Charalampos, Giannopoulos Georgios and Deftereos Spyridon, Calcium Handling and Arrhythmogenesis, Medicinal Chemistry 2016; 12 (2) . https://dx.doi.org/10.2174/157340641202160209102839