A Recent Perspective on Discovery and Development of Diverse Therapeutic Agents Inspired from Isatin Alkaloids

Title:A Recent Perspective on Discovery and Development of Diverse Therapeutic Agents Inspired from Isatin Alkaloids

Volume: 16 Issue: 11

Author(s): Rajesh A. Rane, Sivanandhan Karunanidhi#, Kavita Jain, Mahamadhanif Shaikh, Girish Hampannavar and Rajshekhar Karpoormath

Affiliation:

Keywords: Isatin, Alkaloid, Anticancer agents, Antimicrobial agents, CNS agents, Review.

Abstract: Isatin as an alkaloidal framework have consistently attracted attention of medicinal chemist towards development of wide range of novel therapeutic agents. This review report has discussed significant isatin lead molecules and their derivatives which have shown promising biological potential in recent times. The substituted isatins showing a potent pharmacological activities such as antimicrobial, antitubercular, anticancer, antioxidant, anti-histaminic, anti-HIV, antiviral, anti-inflammatory, anti-Parkinson’s and antidiabetic have been described in this review. The mechanism of action leading to therapeutic activity of the respective isatin derivation has also been recorded. This review reveals that the systematic and rational modifications on isatin motif exhibited significant bio-activities which can be exploited for the development of potent novel therapeutic agents in the future studies. Hence the quest to investigate more structural alterations on isatin scaffold should be continued.

Cite this article as:

Rane A. Rajesh, Karunanidhi# Sivanandhan, Jain Kavita, Shaikh Mahamadhanif, Hampannavar Girish and Karpoormath Rajshekhar, A Recent Perspective on Discovery and Development of Diverse Therapeutic Agents Inspired from Isatin Alkaloids, Current Topics in Medicinal Chemistry 2016; 16 (11) . https://dx.doi.org/10.2174/1568026615666150915112334