以雄激素受体为靶点治疗晚期前列腺癌的新化合物

Title:New Compounds Targeting the Androgen Receptor for Treatment of Advanced Prostate Cancer

Volume: 17 Issue: 3

Author(s): Rita Assi, Sally Temraz, Ali Shamseddine and Deborah Mukherji

Affiliation:

关键词: 前列腺癌，雄激素受体，abiraterone，enzalutamide。

摘要: The androgen receptor (AR) signalling pathway remains a key driver of prostate cancer progression despite castrate levels of testosterone in advanced disease. The androgen biosynthesis inhibitor abiraterone and the anti-androgen enzalutamide have been shown to prolong survival in randomized clinical trials both pre-and post-docetaxel chemotherapy and are now in routine clinical use. With the use of these drugs and other novel survival-prolonging therapeutics, patients with advanced prostate cancer are now living longer with better quality of life. This article will review pre-clinical and clinical data for AR-targeting therapeutics for advanced prostate cancer with a focus on mechanisms of resistance and future directions for research.

Cite this article as:

Rita Assi, Sally Temraz, Ali Shamseddine and Deborah Mukherji , New Compounds Targeting the Androgen Receptor for Treatment of Advanced Prostate Cancer, Current Drug Targets 2016; 17 (3) . https://dx.doi.org/10.2174/1389450116666150907101044