Oleanolic Acid A-lactams Inhibit the Growth of HeLa, KB, MCF-7 and Hep-G2 Cancer Cell Lines at Micromolar Concentrations

Title:Oleanolic Acid A-lactams Inhibit the Growth of HeLa, KB, MCF-7 and Hep-G2 Cancer Cell Lines at Micromolar Concentrations

Volume: 16 Issue: 5

Author(s): Barbara Bednarczyk-Cwynar, Piotr Ruszkowski, Teresa Bobkiewicz-Kozlowska and Lucjusz Zaprutko

Affiliation:

Keywords: Beckmann rearrangement, cytotoxic activity, lactams of oleanolic acid, oleanolic acid derivatives, triterpenes.

Abstract: Oleanolic acid ketones, oximes, lactams and nitriles were obtained. Complete spectral characterizations (IR, ¹H NMR, ¹³C NMR, DEPT and MS) of the synthesized compounds are presented. The derivatives had oxo, hydroxyimino, lactam or nitrile functions at the C-3 position, an esterified or unmodified carboxyl group at the C- 17 location and, in some cases, an additional oxo function at the C-11 position. The new compounds were tested for cytotoxic activity on the HeLa, KB, MCF-7 and Hep-G2 cancer cell lines with the application of MTT [3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] test. Among the tested compounds, some oximes and all lactams proved to be the most active cytotoxic agents. These triterpenes significantly inhibited the growth of the HeLa, KB, MCF-7 and Hep-G2 cancer cell lines at micromolar concentrations.

Cite this article as:

Bednarczyk-Cwynar Barbara, Ruszkowski Piotr, Bobkiewicz-Kozlowska Teresa and Zaprutko Lucjusz, Oleanolic Acid A-lactams Inhibit the Growth of HeLa, KB, MCF-7 and Hep-G2 Cancer Cell Lines at Micromolar Concentrations, Anti-Cancer Agents in Medicinal Chemistry 2016; 16 (5) . https://dx.doi.org/10.2174/1871520615666150907095756