An Efficient Way to Synthesize N-(β-Nitroalkyl) Amides through Ritter Reaction

Ronghua      Shi; Wensi      Ai; Tao      He; Xiaobo      Ma; Shan      Qian; Zhouyu      Wang

doi:10.2174/1570178612666150903213036

Abstract

An efficient and simple way to synthesize N-(β-nitroalkyl) amides with broad substrate spectrum was developed. Various β-nitroarylethanols and nitriles were suitable substrate for the protocol. A series of N-(β-nitroalkyl) amides were synthesized through Ritter reaction and the yield is up to 95%.

Keywords: Alcohols, amides, carbocation, catalysis, nitriles.

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Letters in Organic Chemistry

Title:An Efficient Way to Synthesize N-(β-Nitroalkyl) Amides through Ritter Reaction

Volume: 12 Issue: 10

Author(s): Ronghua Shi, Wensi Ai, Tao He, Xiaobo Ma, Shan Qian and Zhouyu Wang

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Keywords: Alcohols, amides, carbocation, catalysis, nitriles.

Abstract: An efficient and simple way to synthesize N-(β-nitroalkyl) amides with broad substrate spectrum was developed. Various β-nitroarylethanols and nitriles were suitable substrate for the protocol. A series of N-(β-nitroalkyl) amides were synthesized through Ritter reaction and the yield is up to 95%.

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Shi Ronghua, Ai Wensi, He Tao, Ma Xiaobo, Qian Shan and Wang Zhouyu, An Efficient Way to Synthesize N-(β-Nitroalkyl) Amides through Ritter Reaction, Letters in Organic Chemistry 2015; 12 (10) . https://dx.doi.org/10.2174/1570178612666150903213036

DOI https://dx.doi.org/10.2174/1570178612666150903213036	Print ISSN 1570-1786
Publisher Name Bentham Science Publisher	Online ISSN 1875-6255