Advances in Research on Pharmacological Activities and Synthesis of Oleanolic Acid Derivatives at C-3 Position

Title:Advances in Research on Pharmacological Activities and Synthesis of Oleanolic Acid Derivatives at C-3 Position

Volume: 5 Issue: 3

Author(s): Qutong Zheng, Yi Liu, Hongfei Chen, Yan Xiao, Xianliang Zeng, Yun Wei, Xinrui Luo, Xuan Xiao, Zongbao Wang and Xing Zheng

Affiliation:

Keywords: C-3 position, oleanolic acid, oleanolic acid derivatives, pharmacological activities, research, synthesis.

Abstract: Oleanolic acid (3β-hydroxyolean-12-en-28-oic acid) belongs to pentacyclic triterpenoid compounds which are widely found in natural plants. Oleanolic acid and its derivatives possess several promising pharmacological activities. The chemical modifications made in the oleanane backbone mainly at carbons C3, C12 and C28 carboxylic acid, have led to a series of new synthetic oleanane triterpenoids. The Oleanolic acid derivatives at C-3 position exhibited the most potent activity. Here, a review of the advances in research on pharmacological activities and synthesis of Oleanolic acid derivatives at C-3 position are presented.

Cite this article as:

Zheng Qutong, Liu Yi, Chen Hongfei, Xiao Yan, Zeng Xianliang, Wei Yun, Luo Xinrui, Xiao Xuan, Wang Zongbao and Zheng Xing, Advances in Research on Pharmacological Activities and Synthesis of Oleanolic Acid Derivatives at C-3 Position, The Natural Products Journal 2015; 5 (3) . https://dx.doi.org/10.2174/2210315505666150827214022