关于褪黑激素对一些抗传染性病原体的潜在相关性的研究和评估

Title:Potential Relevance of Melatonin Against Some Infectious Agents: A Review and Assessment of Recent Research

Volume: 22 Issue: 33

Author(s): Ehab Kotb Elmahallawy, Javier Ortega Luque, Abdelkarim Saleh Aloweidi, Jose Gutierrez -Fernandez and Antonio Sampedro-Martinez, Javier Rodriguez-Granger, Abdullah Kaki and Ahmad Agil

Affiliation:

关键词: 细菌和病毒感染，免疫系统调节，离子通量，褪黑激素，寄生虫，治疗效果。

摘要: Melatonin, a tryptophan-derived neurohormone found in animals, plants, and microbes, participates in various biological and physiological functions. Among other properties, numerous in vitro or in vivo studies have reported its therapeutic potential against many parasites, bacteria and viruses. In this concern, melatonin was found to be effective against many parasites such as Plasmodium, Toxoplasma gondii, and Trypansoma cruzi, via various mechanisms such as modulation of calcium level and/or host immune system. Likewise, a recent investigation has reported in vitro activity of melatonin against Leishmania infantum promastigotes which is the causative agent of fascinating visceral Leishmaniasis. This review was initially undertaken to summarize some facts about certain physiological and therapeutic effects of melatonin. It also reviews the effects and action mechanisms of melatonin in bacterial and viral infection besides biology of different parasites which may provide a promising strategy for control of many diseases of public health importance.

Cite this article as:

Ehab Kotb Elmahallawy, Javier Ortega Luque, Abdelkarim Saleh Aloweidi, Jose Gutierrez -Fernandez and Antonio Sampedro-Martinez, Javier Rodriguez-Granger, Abdullah Kaki and Ahmad Agil , Potential Relevance of Melatonin Against Some Infectious Agents: A Review and Assessment of Recent Research, Current Medicinal Chemistry 2015; 22 (33) . https://dx.doi.org/10.2174/0929867322666150827093730