Abstract
The chimeric antigen receptor (CAR) technology started out as a tool to understand lymphocyte biology but rapidly developed into a T cell therapeutic agent for the treatment of cancers. Here, we describe the technological advances in the field of CARs and highlight critical components of its success. Additionally, we describe how various laboratories have worked toward developing new, safer, and more potent CARs for cancer.
Keywords: Cell therapy, chimeric antigen receptor (CAR), gene therapy, synthetic biology.
Graphical Abstract
Current Drug Targets
Title:Chimeric Antigen Receptor T Cells: Self-Replicating Drugs for Cancer
Volume: 18 Issue: 3
Author(s): Jan J. Melenhorst, Simon F. Lacey and Felipe Bedoya
Affiliation:
Keywords: Cell therapy, chimeric antigen receptor (CAR), gene therapy, synthetic biology.
Abstract: The chimeric antigen receptor (CAR) technology started out as a tool to understand lymphocyte biology but rapidly developed into a T cell therapeutic agent for the treatment of cancers. Here, we describe the technological advances in the field of CARs and highlight critical components of its success. Additionally, we describe how various laboratories have worked toward developing new, safer, and more potent CARs for cancer.
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Cite this article as:
Melenhorst J. Jan, Lacey F. Simon and Bedoya Felipe, Chimeric Antigen Receptor T Cells: Self-Replicating Drugs for Cancer, Current Drug Targets 2017; 18 (3) . https://dx.doi.org/10.2174/1389450116666150825120427
DOI https://dx.doi.org/10.2174/1389450116666150825120427 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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