(-)-表没食子儿茶素-3-没食子酸酯(EGCG)在阿尔茨默海病二级预防中的潜在作用

Title:Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease

Volume: 18 Issue: 2

Author(s): Laura Xicota, Jose Rodriguez-Morato, Mara Dierssen, Rafael de la Torre

Affiliation:

关键词: 阿尔茨海默病

摘要: Medical advances in the last decades have increased the average life expectancy, but also the incidence and prevalence of age-associated neurodegenerative diseases. Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases and the most prevalent type of dementia. A plethora of different mechanisms contribute to AD, among which oxidative stress plays a key role in its development and progression. So far, there are no pharmacological treatments available and the current medications are mainly symptomatic. In the last years, dietary polyphenols have gained research attention due to their interesting biological activities, and more specifically their antioxidant properties. (-)- Epigallocatechin-3-gallate (EGCG) is a natural flavanol that has been extensively studied regarding its potential effects in AD. In this review we present the current in vitro and in vivo experimentation regarding the use of EGCG in AD. We also review the complex mechanisms of action of EGCG, not only limited to its antioxidant activity, which may explain its beneficial health effects.

Cite this article as:

Laura Xicota, Jose Rodriguez-Morato, Mara Dierssen, Rafael de la Torre , Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease, Current Drug Targets 2017; 18 (2) . https://dx.doi.org/10.2174/1389450116666150825113655