抑制磷酸-N-乙酰胞壁酸-五肽移位酶的抗菌性核苷天然产物；化学与结构活性之间的关系

Title:Antibacterial Nucleoside Natural Products Inhibiting Phospho-MurNAc-Pentapeptide Translocase; Chemistry and Structure-Activity Relationship.

Volume: 22 Issue: 34

Author(s): S. Ichikawa, M. Yamaguchi and A. Matsuda

Affiliation:

关键词: 核苷抗生素，MraY，天然产物，抗菌药，耐药性，总合成

摘要: The continued emergence of drug-resistance to existing antibacterial agents represents a severe and ongoing public health concern, which demands the discovery of new antibiotics. However the number of novel classes of antibacterial drugs launched in the clinic has been remarkably slow since the 1960s, and it is urgent to develop novel antibacterial agents to fight against drug-resistant bacterial pathogens. Peptidoglycan is a component of the bacterial cell wall, which consists of a repeated N-acetylmuramic acid (MurNAc) and Nacetylglucosamine (GluNAc) polymer cross-linked with polypeptides, and is a good target for antibacterial drug discovery. Among enzymes responsible for its biosynthesis, phospho-MurNAc-pentapeptide translocase (MraY) is a novel and promising target. Many nucleoside natural products, which strongly inhibit MraY, have been found in nature. This review will summarize the synthesis and biological properties of selected MraY inhibitory nucleoside natural products and their analogues synthesized in our laboratory and by others.

Cite this article as:

S. Ichikawa, M. Yamaguchi and A. Matsuda , Antibacterial Nucleoside Natural Products Inhibiting Phospho-MurNAc-Pentapeptide Translocase; Chemistry and Structure-Activity Relationship., Current Medicinal Chemistry 2015; 22 (34) . https://dx.doi.org/10.2174/0929867322666150818103502