Room Temperature Metal-Free Synthesis of Aryl/Heteroaryl-Substituted Bis(6-aminouracil-5-yl)methanes Using Sulfamic Acid (NH2SO3H) as an Efficient and Eco-friendly Organo-Catalyst

Title:Room Temperature Metal-Free Synthesis of Aryl/Heteroaryl-Substituted Bis(6-aminouracil-5-yl)methanes Using Sulfamic Acid (NH2SO3H) as an Efficient and Eco-friendly Organo-Catalyst

Volume: 3 Issue: 2

Author(s): Bubun Banerjee and Goutam Brahmachari

Affiliation:

Keywords: Aqueous ethanol, bis(6-aminouracil-5-yl)methanes, eco-friendly, no column chromatography, room-temperature, sulfamic acid.

Abstract: A simple, straightforward and eco-friendly protocol for the synthesis of pharmaceuticallyinteresting aryl/heteroaryl-substituted bis(6-aminouracil-5-yl)methane derivatives has been developed using sulfamic acid (NH₂SO₃H) as a cost-effective and non-toxic organo-catalyst via pseudomulticomponent reaction of 6-amino-1,3-dimethyluracil with aromatic/heteroaromatic aldehydes in aqueous ethanol at room temperature. Mild reaction conditions, good to excellent yields, ecofriendliness, easy isolation of products and avoidance of column chromatographic separation are some of the notable features of this protocol.

Cite this article as:

Banerjee Bubun and Brahmachari Goutam, Room Temperature Metal-Free Synthesis of Aryl/Heteroaryl-Substituted Bis(6-aminouracil-5-yl)methanes Using Sulfamic Acid (NH2SO3H) as an Efficient and Eco-friendly Organo-Catalyst, Current Organocatalysis 2016; 3 (2) . https://dx.doi.org/10.2174/2213337202666150812231130