新多巴胺转运蛋白抑制剂的研究进展

Title:Progress in the Search for New Dopamine Transporter Inhibitors

Volume: 22 Issue: 28

Author(s): Beata Gryzlo, Paula Zareba, Katarzyna Malawska, Anna Jakubowska and Katarzyna Kulig

Affiliation:

关键词: 可卡因滥用，抑郁症，多动症，多巴胺转运蛋白抑制剂，单胺转运体抑制剂，莨菪烷衍生物。

摘要: In the present review, we provide a comprehensive summary of recent pharmacological studies on dopamine transporter (DAT) inhibitors, which are potential treatments for neurodegenerative and psychiatric disorders. Extensive structure-activity relationship studies have identified numerous tropane-based ligands with high affinity and selectivity for the DAT or with high affinity to the DAT and other monoamine transporters (dual and triple monoamine reuptake inhibitors). The review covers advances in the field in past fifteen years. Among the described compounds, many appear to be promising drug candidates, while other may serve as valuable tools for research or as prototypes for new classes of selective DAT inhibitors. Special attention is being paid to separation of the DAT inhibition from NET and SERT inhibition.

Cite this article as:

Beata Gryzlo, Paula Zareba, Katarzyna Malawska, Anna Jakubowska and Katarzyna Kulig , Progress in the Search for New Dopamine Transporter Inhibitors, Current Medicinal Chemistry 2015; 22 (28) . https://dx.doi.org/10.2174/0929867322666150812145631