Peroxisome Proliferator-Activated Receptor-γ and Its Ligands in the Treatment of Tumors in the Nervous System

Title:Peroxisome Proliferator-Activated Receptor-γ and Its Ligands in the Treatment of Tumors in the Nervous System

Volume: 11 Issue: 3

Author(s): Yun Shen, Yun Lu, Fang Yu, Chuntie Zhu, Hua Wang and Jing Wang

Affiliation:

Keywords: Anti-tumor, chemoprevention, glioblastoma, nervous system, neuroblastoma, peroxisome proliferator-activated receptor γ, thiazolidinediones (TZDs).

Abstract: The peroxisome proliferator-activated receptor –γ (PPARγ) has been identified in a wide range of cancers, including brain, breast, colon, stomach and lung cancers. It belongs to the thyroid/ steroid hormone receptors superfamily. Binding with their special ligands, PPARγ plays important roles in regulating transcription of their target genes. PPARγ activation suppresses the growth of the tumor cells, implicating the anti-tumor potential of PPARγ ligand. Tumors in the nervous system are among the most devastating cancers. This review highlights key advances in understanding the effects of PPARγ ligands in the treatment of tumors in the nervous system.

Cite this article as:

Shen Yun, Lu Yun, Yu Fang, Zhu Chuntie, Wang Hua and Wang Jing, Peroxisome Proliferator-Activated Receptor-γ and Its Ligands in the Treatment of Tumors in the Nervous System, Current Stem Cell Research & Therapy 2016; 11 (3) . https://dx.doi.org/10.2174/1574888X10666150728122034