Synthesis of Porphyrin, Chlorin and Phthalocyanine Derivatives by Azide-Alkyne Click Chemistry

Samir Acherar, Ludovic Colombeau, Celine Frochot and Regis Vanderesse

doi:10.2174/0929867322666150716115832

摘要

本文旨对铜催化叠氮炔环加成在具有不同类型治疗作用的卟啉、氯和酞菁衍生物合成中的应用。点击反应是研究各种对称和不对称取代四吡咯衍生物合成强有力的科学方法。例如，点击化学广泛用于光动力疗法中光敏剂结合物的阐述。除此之外，点击反应其他生物应用也得到阐述。

关键词: 点击化学， Huisgen环加成反应，光动力疗法，光敏剂，疗效。

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Current Medicinal Chemistry

Title:Synthesis of Porphyrin, Chlorin and Phthalocyanine Derivatives by Azide-Alkyne Click Chemistry

Volume: 22 Issue: 28

Author(s): Samir Acherar, Ludovic Colombeau, Celine Frochot and Regis Vanderesse

Affiliation:

关键词: 点击化学， Huisgen环加成反应，光动力疗法，光敏剂，疗效。

摘要: The aim of this review is to provide a summary of the use of copper-catalyzed azide-alkyne cycloaddition (CuAAC) in the synthesis of porphyrin, chlorin and phthalocyanine derivatives for different types of therapeutic applications. The click reaction is a powerful and versatile tool for scientists working on the synthesis of various symmetrically and asymmetrically substituted tetrapyrrolic derivatives. For example, click chemistry is widely used for the elaboration of photosensitizer conjugates for photodynamic therapy applications. Other biological applications are also described.

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Samir Acherar, Ludovic Colombeau, Celine Frochot and Regis Vanderesse , Synthesis of Porphyrin, Chlorin and Phthalocyanine Derivatives by Azide-Alkyne Click Chemistry, Current Medicinal Chemistry 2015; 22 (28) . https://dx.doi.org/10.2174/0929867322666150716115832

DOI https://dx.doi.org/10.2174/0929867322666150716115832	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X