Abstract
The circadian clock is a biological system that allows organisms to adapt to temporal constraints of the environment. It governs all body functions. The circadian clock has an endogenous period and entrains to the external day by the means of timing cues, also called “zeitgebers”. A discrepancy between internal and external day or internal day and certain body functions results in circadian desynchrony, most prominently represented in jet lag. Circadian desynchrony may be a factor in many diseases. This review presents literature in which the impact of circadian desynchrony on disease development - with a special focus on critical illness - has been addressed. The treatment options that have so far been investigated are also presented.
Keywords: Cancer, circadian, circadian desynchrony, circadian disruption, critical illness, entrainment, social jet lag.
Current Pharmaceutical Design
Title:Humans Entrain to Sunlight - Impact of Social Jet Lag on Disease and Implications for Critical Illness
Volume: 21 Issue: 24
Author(s): Jan Remi
Affiliation:
Keywords: Cancer, circadian, circadian desynchrony, circadian disruption, critical illness, entrainment, social jet lag.
Abstract: The circadian clock is a biological system that allows organisms to adapt to temporal constraints of the environment. It governs all body functions. The circadian clock has an endogenous period and entrains to the external day by the means of timing cues, also called “zeitgebers”. A discrepancy between internal and external day or internal day and certain body functions results in circadian desynchrony, most prominently represented in jet lag. Circadian desynchrony may be a factor in many diseases. This review presents literature in which the impact of circadian desynchrony on disease development - with a special focus on critical illness - has been addressed. The treatment options that have so far been investigated are also presented.
Export Options
About this article
Cite this article as:
Remi Jan, Humans Entrain to Sunlight - Impact of Social Jet Lag on Disease and Implications for Critical Illness, Current Pharmaceutical Design 2015; 21 (24) . https://dx.doi.org/10.2174/1381612821666150706110228
DOI https://dx.doi.org/10.2174/1381612821666150706110228 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Association Between Heart Rate Variability and Parkinson’s Disease: A Meta-analysis
Current Pharmaceutical Design Coronary Microcirculation in Heart Failure with Preserved Systolic Function
Current Pharmaceutical Design Bioactive Proteins and Peptides from Soybeans
Recent Patents on Food, Nutrition & Agriculture Cardiovascular and Systemic Risk in Nonalcoholic Fatty Liver Disease - Atherosclerosis as a Major Player in the Natural Course of NAFLD
Current Pharmaceutical Design Advancement in Microsponge Drug Delivery System: Preparation Methods, Patents and Commercial Utility
Recent Patents on Drug Delivery & Formulation Catheter Ablation of Lone Atrial Fibrillation
Current Pharmaceutical Design Identification and Treatment of Patients with Early COPD
Current Respiratory Medicine Reviews Clinical Resolution of Type 2 Diabetes with Reduction in Body Mass Index Using Meal Replacement Based Weight Loss
Vascular Disease Prevention (Discontinued) Neuroprotective Therapies for Alzheimers Disease
Current Pharmaceutical Design Therapeutic Potential of Natural Compounds that Regulate the Activity of Protein Kinase C
Current Medicinal Chemistry Prevention of Respiratory Syncytial Virus: A Review
Current Respiratory Medicine Reviews Current Pharmacological Approach to Restore Endothelial Dysfunction
Cardiovascular & Hematological Agents in Medicinal Chemistry Natural Product-Derived Small Molecule Activators of Hypoxia-Inducible Factor-1 (HIF-1)
Current Pharmaceutical Design 3D Cell and Scaffold Patterning Strategies in Tissue Engineering
Recent Patents on Biomedical Engineering (Discontinued) Bioresorbable Vascular Scaffold: Our Initial Experience
Applied Clinical Research, Clinical Trials and Regulatory Affairs Cyclooxygenase Inhibition and Atherothrombosis
Current Drug Targets Innate Immune Inflammatory Response in the Acutely Ischemic Myocardium
Medicinal Chemistry Hypertension in Egypt: A Systematic Review
Current Hypertension Reviews Inhibition of Transcription Factors by Plant-Derived Compounds and their Implications in Inflammation and Cancer
Current Pharmaceutical Design Cardiovascular Disease in Systemic Lupus Erythematosus: The Role of Traditional and Lupus Related Risk Factors
Current Cardiology Reviews