Collateral Damage: Contribution of Peripheral Inflammation to Neurodegenerative Diseases

Title:Collateral Damage: Contribution of Peripheral Inflammation to Neurodegenerative Diseases

Volume: 15 Issue: 21

Author(s): Antonio J. Herrera, Ana M. Espinosa-Oliva, Maria J. Oliva-Martin, Alejandro Carrillo-Jimenez, Jose L. Venero and Rocio M. de Pablos

Affiliation:

Keywords: Gut-brain axis, Inflammatory bowel disease, Microglia, Neurodegeneration, Parkinson’s disease, Peripheral inflammation.

Abstract: Neurodegenerative diseases are characterized by a progressive deterioration of brain function, with a consequent significant decline in the quality of life of patients and their families. Due to the concurrent increase in life expectancy, the incidence of these diseases has been increasing over the last years and thus there is a growing interest in finding potential risk factors. This review focuses on the correlation between peripheral inflammatory diseases and neurodegeneration, in particular on the relationship between gastrointestinal disorders and Parkinson's disease, especially through the so called gut-brain axis.

Cite this article as:

Herrera J. Antonio, Espinosa-Oliva M. Ana, Oliva-Martin J. Maria, Carrillo-Jimenez Alejandro, Venero L. Jose and de Pablos M. Rocio, Collateral Damage: Contribution of Peripheral Inflammation to Neurodegenerative Diseases, Current Topics in Medicinal Chemistry 2015; 15 (21) . https://dx.doi.org/10.2174/1568026615666150610142027