In Vitro Protective Potentials of Annona muricata Leaf Extracts Against Sodium Arsenite-induced Toxicity

Title:In Vitro Protective Potentials of Annona muricata Leaf Extracts Against Sodium Arsenite-induced Toxicity

Volume: 12 Issue: 1

Author(s): Vazhappilly Cijo George, Devanga Ragupathi Naveen Kumar, Palamadai Krishnan Suresh and Rangasamy Ashok Kumar

Affiliation:

Keywords: Annona muricata, erythrocytes, sodium arsenite, WRL-68.

Abstract: Sodium arsenite (NaAsO2) is a metalloid which is present widely in the environment and its chronic exposure can contribute to the induction of oxidative stress, resulting in disturbances in various metabolic functions including liver cell death. Hence, there is a need to develop drugs from natural sources, which can reduce arsenic toxicity. While there have been reports regarding the antioxidant and protective potentials of Annona muricataleaf extracts, our study is the first ofits kind to extend these findings by specifically evaluating its ability to render protection against sodium arsenite (NaAsO2) induced toxicity (10 μM) in WRL-68 (human hepatic cells) and human erythrocytes by employing XTT and haemolysis inhibition assays respectively. The methanolic extract exhibited higher activity than the aqueous extract in both assays. The results showed a dose-dependent decrease in arsenic toxicity in both WRL-68 cells and erythrocytes, suggesting the protective nature of Annona muricatato mitigate arsenic toxicity. Hence the bioactive extracts can further be scrutinized for the identification and characterization of their principal contributors.

Cite this article as:

George Cijo Vazhappilly, Naveen Kumar Ragupathi Devanga, Suresh Krishnan Palamadai and Kumar Ashok Rangasamy, In Vitro Protective Potentials of Annona muricata Leaf Extracts Against Sodium Arsenite-induced Toxicity, Current Drug Discovery Technologies 2015; 12 (1) . https://dx.doi.org/10.2174/1570163812666150602144154