SUMO化修饰调节CFTR的生源论：是一个药物开发的途径吗？

Title:SUMOylation Modulates CFTR Biogenesis: Is the Pathway Druggable?

Volume: 16 Issue: 9

Author(s): Annette Ahner and Raymond A. Frizzell

Affiliation:

关键词: SAE1/SAE2，Ubc9，SUMO E3，Hsp27，SUMO，SUMO肽酶，SUMO 相关修饰物

摘要: The SUMOylation pathway is involved in the regulation of numerous and diverse cellular functions, nuclear as well as extra-nuclear. Thus, it is not surprising that SUMO pathway components are implicated in diseases as diverse as cystic fibrosis, cancer and neurodegenerative diseases. Therefore, the components of the SUMOylation pathway should provide valid therapeutic targets for manipulation. While the related ubiquitylation system encompasses a vast number of enzymes as potential drug targets, there are only a handful of components that comprise the SUMOylation cascade. Whereas this alleviates the problem of target redundancy, it may complicate the potential to achieve drug specificity. The development of small molecule inhibitors aimed at SUMO pathway components is in its early stages. This review provides an outline of the pathway and summarizes drug development efforts targeted at individual SUMOylation pathway components, with an emphasis on how CFTR protein processing may be affected.

Cite this article as:

Annette Ahner and Raymond A. Frizzell , SUMOylation Modulates CFTR Biogenesis: Is the Pathway Druggable?, Current Drug Targets 2015; 16 (9) . https://dx.doi.org/10.2174/1389450116666150531152236